上海体育学院学报

2017, (01) 38-42

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间歇低氧结合运动对IR大鼠血清及股四头肌抗氧化能力的影响
The Effects of Intermittent Hypoxia Combined with Exercise on Insulin Resistant Rats' Antioxidant Capacity of Serum and Quadriceps

杨贵明;范锦勤;翁锡全
YANG Guiming; FAN Jinqin; WENG Xiquan

摘要(Abstract):

目的:探讨间歇性低氧暴露结合有氧运动对胰岛素抵抗(IR)大鼠的抗氧化能力的影响。方法:选择健康普食大鼠12只设为普食常氧安静组(NNC),将高脂诱导的胰岛素抵抗大鼠分为常氧安静组(NC)、低氧安静组(HC)、常氧运动组(NE)和低氧运动组(HE),并进行4周的间歇低氧和跑台运动干预。结果:①与NC组比较,3个干预组血清的T-AOC、SOD和GSH-Px均升高且具有统计学意义,MDA均下降且具有统计学意义;3个干预组股四头肌的MDA均下降且具有统计学意义,HC组的GSH-Px升高且具有统计学意义,NE组和HE组的T-AOC、SOD和GSH-Px均升高且具有统计学意义。②与NNC组比较,3个干预组的血清SOD均升高且具有统计学意义,NE组和HE组的血清GSH-Px均升高且具有统计学意义;HC组股四头肌的MDA降低具有统计学意义,NE组股四头肌的SOD升高有统计学意义,HE组的股四头肌MDA降低和GSH-Px升高均具有统计学意义。结论:间歇低氧、运动和间歇低氧结合运动均可改善高脂饲料诱导IR大鼠血液和股四头肌的抗氧化能力,其中以间歇低氧结合运动组效果最好。
Objective:To study the effects of the antioxidant capacity on SD rats' insulin resistance by intermittent hypoxic exposure combined with aerobic exercise. Methods:The healthy rats with normal fodder were selected to be normal oxygen control group (NNC).The rats with insulin resistance were divided into normal oxygen control group (NC), hypoxic control group (HC), normal oxygen exercise group (NE) and hypoxic exercise group (HE).The prevention of oxygen concentration of intermittent hypoxia and treadmill exercises were conducted for 4 weeks. Results:①Compared with the NC group, the serum's T-AOC, SOD and GSH-Px all increased and the serum's MDA in the other three groups all decreased (p<0.05); while the quadriceps' MDA in the 3 groups all decreased. The quadriceps' GSH-Px in the HC group increased; while the quadriceps' T-AOC and SOD in both the NE group and the HE group increased. ② Compared with the NNC group, the serum's SOD in the other three groups all increased while the serum's GSH-Px in both the NE group and the HE group increased. The quadriceps' MDA in the HC group decreased while the quadriceps' SOD in the NE group increased. The quadriceps' MDA in the HE group decreased while its GSH-Px decreased. Conclusion:The intervention of the intermittent hypoxia, exercise and intermittent hypoxia combining exercise can improve the IR rats' serum and quadriceps' antioxidant capacity; and the intermittent hypoxia combining exercise show the best effect.

关键词(KeyWords): 胰岛素抵抗;大鼠;间歇低氧;跑台运动;抗氧化能力;血清;股四头肌
insulin resistance;rat;intermittent hypoxia;treadmill exercise;antioxidant capacity;serum;quadriceps

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作者(Author): 杨贵明;范锦勤;翁锡全
YANG Guiming; FAN Jinqin; WENG Xiquan

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